FELBAMATE PACKAGE INSERT PDF

See package insert. How to take and store Felbamate? Follow your doctor’s directions. Call if you have any questions. Usually, your doctor will tell you to start by. Felbatol is the brand name used in the United States for felbamate. Read the black box warning in the Package Insert to your patient and obtain any necessary . Felbamate, also known as Felbatol, has been approved by the Food and Drug about all potential risks before using this drug and read the package insert.

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Time to peak serum concentration is 1—6 hours. Use felbamate with caution in patients with pre-existing renal impairment, particularly renal failure. Minor The metabolism of dapsone may be accelerated when administered concurrently with felbamate, a known inducer of CYP3A4. Major Avoid concurrent use of dolutegravir with felbamate, as coadministration may result in decreased dolutegravir plasma concentrations.

Patients sensitive to carbamate derivatives e. Felbamate is a potent inhibitor of CYP2C Adverse effects, such as sedation, lethargy, ataxia, or insomnia may be potentiated.

Major Based on very limited data, it appears felbamate can accelerate the clearance of the estrogen component of some oral contraceptives. In addition, seizures have been reported during the use of molindone, which is of particular significance in patients with a seizure disorder receiving anticonvulsants.

Anticonvulsants may cause liver dysfunction, blood dyscrasias, and serious skin rashes requiring treatment discontinuation. Valproic Acid, Divalproex Sodium: When an anticonvulsant is being used to manage behavior, stabilize mood, or treat a psychiatric disorder, the facility should attempt periodic tapering of the medication or provide documentation of medical necessity in accordance with OBRA guidelines. Belladonna Alkaloids; Ergotamine; Phenobarbital: Monitor for a decrease in maraviroc efficacy with concomitant use.

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If these drugs must be administered together, closely monitor for a reduction in dapsone efficacy and signs of hemolytic anemia. Moderate Monitor for clinical efficacy of etoposide if used concomitantly with felbamate.

Coadministration may decrease the plasma concentrations of isavuconazole resulting in the potential for treatment failure. Felbamate should be discontinued if signs and symptoms of hematologic abnormalities or any sign of bone marrow depression occurs.

Major Avoid coadministration of isavuconazonium with felbamate.

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Moderate Amoxapine, when used concomitantly with anticonvulsants, can increase CNS depression and may also lower the seizure threshold, packkage to pharmacodynamic interactions.

Therefore, use of praziquantel with felbamate, a CYP3A4 inducer, should be done with caution as concomitant use may produce therapeutically ineffective concentrations of praziquantel. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Felbamate is contraindicated in patients with a felbamate or carbamate hypersensitivity.

Major Avoid concurrent use of felbamate with bedaquiline. There were 4 completed suicides among patients in drug treatment groups versus none in the placebo groups.

Moderate Felbamate has been shown to increase valproic acid serum concentrations, however the magnitude of this effect varies. Moderate Hydantoins are hepatic enzyme inducers and thus may accelerate the metabolism of several other anticonvulsants, including felbamate. Patients receiving these drugs concurrently with vincristine should be monitored for possible loss of vincristine efficacy.

Any patient withdrawn from the drug for liver injury are considered at increased risk for such problems if the drug is re-introduced. The intended therapeutic effect of clarithromycin could be decreased.

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Patients must call to enroll in the registry. Felbamate is contraindicated in patients with current or previous hepatic disease or dysfunction e. If use together is necessary, obtain an ECG prior pacmage lacosamide initiation and after treatment has been titrated to steady-state.

The manufacturer advises to avoid use of felbamate in patients with pre-existing hepatic disease. Minor Coadministration of rivaroxaban and felbamate may result in decreased rivaroxaban exposure and may decrease the efficacy of rivaroxaban.

Felbatol (felbamate) dose, indications, adverse effects, interactions from

Moderate Concurrent administration of felbamate and other antiepileptic drugs results in changes in serum concentrations of both felbamate and the antiepileptic drugs. In addition, monitor patients receiving lacosamide via the intravenous route closely.

Minor Bone marrow suppression is associated with guanidine therapy. Packgae is a mild inducer of the hepatic isoenzyme CYP3A4; ritonavir, paritaprevir, and dasabuvir minor are metabolized by this enzyme.

Determining effectiveness and tolerability through evaluation of symptoms should be used to adjust doses. Moderate Concomitant use of systemic lidocaine and felbamate may decrease lidocaine plasma concentrations. In Septemberthe manufacturer issued a letter stating 8 cases of acute hepatic failure, including 4 deaths, were associated with the use of felbamate.